Mesotherapy and Cryolipolysis: The Aesthetic Duo to Reduce Size and Combat Cellulitis before Summer
The strategic combination of Criolipolisis and Mesotherapy has been established in Spanish aesthetic medicine as the most powerful and non-invasive protocol for pre-summer body remodeling. They address in a complementary way the major challenges of the silhouette: the reduction of fat due to localized adiposity and the correction of cellulitis (orange skin), problems that often coexist and are resistant to exercise.
- Cryolipolysis: The Attack on Localized Adiposisity (Scale Reduction)
Criolipolisis is the technique of choice for the selective and permanent destruction of deep and localized grease.
¿Qué es y Cómo Funciona?
Mechanism: It is based on the principle that adipocytes (fat cells) are more sensitive to cold than other surrounding tissues (skin, nerves, muscles). A head suctions the grease plug (the “pellizco”) and cools it in a controlled way at temperatures between –5 °C and –11 °C for a specific time (between 45 and 60 minutes).
Apoptosis: Extreme cold induces apoptosis (programmed cell death) of adipocytes. These dead cells are gradually eliminated by the lymphatic system and the body's natural metabolism in the weeks and months following treatment.
Key Indications: Localized adiposity is well delimited and palpable, especially in areas such as:
Abdomen (lower and upper)
Flanks (“michelines”)
“Cartucheras” (trochanters)
Cara interna de los muslos
Double chin (with specific applicators)
Results and Process
Process: It is a shock treatment that generally requires 1 or 2 sessions per area, with an interval of 6 to 8 weeks between them.
Effect: Reduce the fat volume of the treated area permanently (since destroyed adipocytes will not regenerate).
- Mesotherapy: Draining, Lipolitics and Anti-cellulite
Mesotherapy is an intradermal injection technique that is used to improve tissue quality, drain and dissolve residual grease.
¿Qué es y Cómo Funciona?
Mechanism: Consists of the injection of microdosis of personalized cocktails just below the skin. These cocktails penetrate directly into the tissue without passing through the digestive system.
Types of Cocteles and Applications:
Lipolitics: Infiltration of substances such as L-Carnitine or Desoxycolic Acid. Its objective is to mobilize or dissolve the most superficial grease.
Drainage/Circulatory: Assets that improve microcirculation and eliminate liquids and toxins. It is the pillar of treatment against Edematous Cellulitis.
Firming: Organic silicon or vitamins that stimulate collagen synthesis, improving skin sagging that often accompanies cellulitis.
Key Indications:
Cellulitis (Narange Skin): Acts on the three phases of cellulitis (edematous, fibrous and adipose).
Mild sagging.
Post-Cryolipolysis Supplement.
Results and Process
Process: A cycle of several sessions is required (generally between 6 and 10), spaced weekly or biennially, as its results are progressive.
Effect: Improves skin quality and appearance, reduces fluid retention and smoothes cellulite nodules.
- El Protocol Duo: The Perfect Synergy
Criolipolisis and Mesotherapy are complementary, as they act in different ways and with different objectives.
Primary Objective Action Cover Technique
Deep Fat Cryolipolysis Volume and Size Reduction
Mesotherapy Superficial Grease and Dermis Combating Cellulitis and Drainage
Implementation of the Pre-Summer Protocol (in Spain)
- Criolipolisis (The Initial Attack): The Criolipolisis session is carried out in areas of greater volume (abdomen, flanks). This is the maximum reduction phase. .
- Drainage Phase (2-3 Weeks Later): Once the body begins to eliminate adipocytes destroyed by the cold, Mesotherapy begins with an emphasis on draining and lipolytic actives. This step is crucial for:
Accelerate the process of eliminating grease treated by Cryolipolysis.
Treat superficial cellulitis surrounding the area.
Reduce inflammation or the slight hematoma that can generate cryolipolysis.
- Maintenance and Tension: Continue with Mesotherapy (combined with Radiofrequency if there is sagging) to reaffirm the skin, improve circulation and prevent the reappearance of cellulitis, refining the contour for the summer.
Essential Accessories
For the duo to be fully effective, it is essential to combine it with supportive therapies:
Manual Lymphatic Drainage (DLM) or Pressotherapy: Essentials behind Mesotherapy and, especially, behind Cryolipolysis. Helps the lymphatic system to process and eliminate cellular waste (destroyed fat).
Hydration and Diet: Drinking plenty of water and maintaining a low-sodium, fiber-rich diet are essential to avoid fluid retention and maximize the draining effect of Mesotherapy.

Mesotherapy and Cryolipolysis: The Aesthetic Duo to Reduce Size and Combat Cellulitis before Summer
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